A multi-layer parametric approach to maximize the access probability of mobile networks

Next-generation mobile networks (5G) are defined to provide access in the framework of heterogeneous systems where it is crucial to have “always on” and “everywhere connectivity” capabilities. This is of fundamental importance even in 4G mobile systems, down to 3G and also Wi-Fi and WiMAX. In order to guarantee access to users with handheld devices equipped with multiple radio interfaces, an automated and reconfigurable tool for selecting the best network to be connected with is needed. This should be achieved by avoiding service outages. Current vertical handovers, i.e., switching from a network to another, are essentially based on power received levels and often do not avoid temporary service outages. We propose in this paper a procedure to access mobile networks by sensing multiple performance parameters related to networks available in the considered area. We target at maximizing the probability of accessing the wireless medium despite the technology used. We develop an algorithm, based on dynamic programming, able to select the most suitable network. We present the performance of the proposed algorithm both on the basis of computer simulations and on tests performed in an Arduino-based hardware platform

Bias extension test for pantographic sheets: numerical simulations based on second gradient shear energies

We consider a bi-dimensional sheet consisting of two orthogonal families of inextensible fibres. Using the representation due to Rivlin and Pipkin for admissible placements, i.e. placements preserving the lengths of the inextensible fibres, we numerically simulate a standard bias extension test on the sheet, solving a non-linear constrained optimization problem. Several first and second gradient deformation energy models are considered, depending on the shear angle between the fibres and on its gradient, and the results obtained are compared. The proposed numerical simulations will be helpful in designing a systematic experimental campaign aimed at characterizing the internal energy for physical realizations of the ideal pantographic structure presented in this paper

MULTIPLE ORGAN HARVESTING: EVOLUTION OF SURGICAL TECHNIQUE. PERSONAL EXPERIENCE

SINCE 1950, kidney, liver, heart, and lung transplantations have dramatically improved, emerging as the elective treatment modality for organ failure. Nevertheless, the indications to pancreas and bowel grafting are stili controversial. Several factors have contributed such results, namely the introduction of cyclosporine (CyA) in 1981, the use of new solutions for solid organ preservation (eg, the University of Wisconsin solution), the improvement in donor selection criteria, intensive care, as well as improvement management of transplant operation and harvesting surgical technique

Raising Awareness on the Clinical and Social Relevance of Adequate Chronic Pain Care

Appropriate pain care should be regarded as a right and effectively guaranteed to people with chronic pain (CP). Law 38, enacted in Italy in 2010, establishes the citizen's right not to suffer. Twelve years later, such right appears still disregarded in Italy and the current access to adequate pain care reveals significant shortcomings. In addition, a mismatch between CP-associated burden and the available healthcare resources in the framework of our national health system has been observed. This article gathers the perspectives of a Board of Italian anesthesiologists on the state of the art of CP management in Italy and aims at strengthening the scientific rationale and clinical relevance of pursuing the enforceability of the right not to suffer and at promoting widespread multidisciplinary care of patients with CP

Molecular targets of developmental exposure to bisphenol A in diabesity: a focus on endoderm-derived organs

Several studies associate foetal human exposure to bisphenol A (BPA) to metabolic/endocrine diseases, mainly diabesity. They describe the role of BPA in the disruption of pancreatic beta cell, adipocyte and hepatocyte functions. Indeed, the complexity of the diabesity phenotype is due to the involvement of different endoderm-derived organs, all targets of BPA. Here, we analyse this point delineating a picture of different mechanisms of BPA toxicity in endoderm-derived organs leading to diabesity. Moving from epidemiological data, we summarize the in vivo experimental data of the BPA effects on endoderm-derived organs (thyroid, pancreas, liver, gut, prostate and lung) after prenatal exposure. Mainly, we gather molecular data evidencing harmful effects at low-dose exposure, pointing to the risk to human health. Although the fragmentation of molecular data does not allow a clear conclusion to be drawn, the present work indicates that the developmental exposure to BPA represents a risk for endoderm-derived organs development as it deregulates the gene expression from the earliest developmental stages. A more systematic analysis of BPA impact on the transcriptomes of endoderm-derived organs is still missing. Here, we suggest in vitro toxicogenomics approaches as a tool for the identification of common mechanisms of BPA toxicity leading to the diabesity in organs having the same developmental origin

A Comparison of Times Taken for the Placement of the First portal and Complication Rates between the Veress Needle Technique and the Modified Hasson Technique in Canine Ovariectomy Laparoscopic Surgery

Minimally invasive surgery is increasingly being used in veterinary medicine. Laparoscopic procedures have several advantages compared with open surgery. These include the magnification of the field of surgery, reduced post-surgical pain and associated stress, reduced post-operative infection rates, and decreased hospitalization time. The establishment of a pneumoperitoneum is a critical step; however, this procedure can prolong the operation time, and most of the complications associated with laparoscopic surgery have been attributed to the insertion of devices into the abdominal cavity. Two main techniques have been employed to create pneumoperitoneum: the closed-entry method using the Veress needle and the open Hasson technique. The first portal is necessary to start insufflation and, subsequently, to realize the operative channel to insert the laparoscopic instruments into the abdomen. Many authors have compared the time necessary to create the first portal using different techniques in human medicine, but studies on this topic in veterinary medicine are lacking. In the veterinary medicine literature, complications associated with the creation of a pneumoperitoneum and the placement of ports include spleen, bowel, or bladder injuries; pneumothorax; and subcutaneous emphysema. The aim of the present study was to compare the times required for the placement of the first portal and the creation of pneumoperitoneum, and the rates of intraoperative complications using the Veress needle technique (VNT) and the open modified Hasson technique (MHT). The sample population comprised 30 female dogs who underwent laparoscopic ovariectomies. The dogs were randomly organized into two groups and two different entry techniques were used: Veress needle (VNT = group A) and the modified Hasson technique (MHT = group B). Complications related to abdominal entry were classified as major, in cases of organ perforation, and minor, in cases of subcutaneous emphysema and gas leakage. The VNT and MHT required 374.0 s and 242.9 s, respectively, for the placement of the first portal and for establishing pneumoperitoneum (p < 0.05). Their major complications rates were 20% and 0%, respectively (p < 0.05). Their minor complications rates were 20% and 35%, respectively (p < 0.05). No surgical procedures required laparotomy. The MHT was associated with a lower major complication rate and required less time to create the first portal, compared with the Veress needle technique

Impact behaviour of a new Hemp/Carbon sandwich structure

Abstract This paper aims to present a new sandwich structure comprising of a grid hemp core and carbon skins. Two typology of hemp cores (7 and 8 mm in thickness) that mainly differ in the density values (0.36 and 0.63 g/cm3) were produced by an ad hoc manufacturing process and adopted to produce the sandwich structures under investigation. Aiming to extend the use of natural fibre composites (NFCs) for applications where high impact resistance is required and to replace common materials used as cores with more eco-friendly ones like the proposed hemp core, low velocity impact (LVI) tests and non-destructive (ND) tests were carried out

"Stockpile" of slight transcriptomic changes determines the indirect genotoxicity of low-dose BPA in thyroid cells

Epidemiological and experimental data highlighted the thyroid-disrupting activity of bisphenol A (BPA). Although pivotal to identify the mechanisms of toxicity, direct low-dose BPA effects on thyrocytes have not been assessed. Here, we report the results of microarray experiments revealing that the transcriptome reacts dynamically to low-dose BPA exposure, adapting the changes in gene expression to the exposure duration. The response involves many genes, enriching specific pathways and biological functions mainly cell death/proliferation or DNA repair. Their expression is only slightly altered but, since they enrich specific pathways, this results in major effects as shown here for transcripts involved in the DNA repair pathway. Indeed, even though no phenotypic changes are induced by the treatment, we show that the exposure to BPA impairs the cell response to further stressors. We experimentally verify that prolonged exposure to low doses of BPA results in a delayed response to UV-C-induced DNA damage, due to impairment of p21-Tp53 axis, with the BPA-treated cells more prone to cell death and DNA damage accumulation. The present findings shed light on a possible mechanism by which BPA, not able to directly cause genetic damage at environmental dose, may exert an indirect genotoxic activity